Savannahs ARE domestic cats and should be treated as such. There are some anecdotal stories of adverse events occurring when modified live virus vaccines have been used on exotics so traditionally breeders recommended using only killed virus vaccines on Savannahs as well. There are pros and cons to using both types of vaccines, but I don't think anyone can say that there is any right or wrong answer to the question of which is best.
There have also been warnings about using ketamine as an induction agent for anesthesia - but this is the same for all cats, regardless of breed. These days, ketamine is almost always used in combination with other drugs to create 'cocktail' as an induction agent. To date, I've not heard of any adverse reactions to the cocktail, and in fact have had it used on some of my own Savannahs.
	
		
			
		
		
	
			
			There have also been warnings about using ketamine as an induction agent for anesthesia - but this is the same for all cats, regardless of breed. These days, ketamine is almost always used in combination with other drugs to create 'cocktail' as an induction agent. To date, I've not heard of any adverse reactions to the cocktail, and in fact have had it used on some of my own Savannahs.
 
	             
 
		 
 
		